Version 5.4
Bos taurus Protein: FGR
Summary
InnateDB Protein IDBP-697695.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGR
Protein Name tyrosine-protein kinase Fgr
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015646
InnateDB Gene IDBG-645013 (FGR)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001784 phosphotyrosine binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0034987 immunoglobulin receptor binding
GO:0034988 Fc-gamma receptor I complex binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007229 integrin-mediated signaling pathway
GO:0008360 regulation of cell shape
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030335 positive regulation of cell migration
GO:0043306 positive regulation of mast cell degranulation
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response
GO:0045088 regulation of innate immune response
GO:0045859 regulation of protein kinase activity
GO:0046777 protein autophosphorylation
GO:0050715 positive regulation of cytokine secretion
GO:0050764 regulation of phagocytosis
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0032587 ruffle membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF00017
PF14633
PF07714
PF00018
PF14604
PF07653
PRINTS PR00401
PR00109
PR00452
PIRSF
SMART SM00252
SM00326
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A5PKG9
UniProt Splice Variant
Entrez Gene 516133
UniGene Bt.15822
RefSeq NP_001092461
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142483 DAAA02006345
GenPept AAI42484

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca