Version 5.4
| Bos taurus Protein: CISH | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-698531.2 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | CISH | ||||||||||
| Protein Name | Cytokine-inducible SH2-containing protein | ||||||||||
| Synonyms | |||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Protein | ENSBTAP00000030624 | ||||||||||
| InnateDB Gene | IDBG-645783 (CISH) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity). May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}. | ||||||||||
| Subcellular Localization | |||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | |||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | |||||||||||
| InterPro |
IPR000980
SH2 domain IPR001496 SOCS protein, C-terminal |
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| PFAM |
PF00017
PF14633 PF07525 |
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| PRINTS |
PR00401
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| PIRSF | |||||||||||
| SMART |
SM00252
SM00253 SM00969 |
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| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q2HJ53 | ||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 616753 | ||||||||||
| UniGene | Bt.4321 | ||||||||||
| RefSeq | NP_001040051 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | BC113307 | ||||||||||
| GenPept | AAI13308 | ||||||||||