InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CLINT1

Summary

InnateDB Protein

IDBP-699219.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLINT1

Protein Name

Clathrin interactor 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021559

InnateDB Gene

IDBG-646414 (CLINT1)

Protein Structure

UniProt Annotation

Function

Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Membrane {ECO:0000255PROSITE- ProRule:PRU00243}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. Note=Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans-Golgi network (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008289	lipid binding
GO:0030276	clathrin binding

Biological Process

GO:0006897

endocytosis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005798	Golgi-associated vesicle
GO:0005802	trans-Golgi network
GO:0016020	membrane
GO:0030136	clathrin-coated vesicle
GO:0031410	cytoplasmic vesicle
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001026 Epsin domain, N-terminal
IPR008942 ENTH/VHS
IPR011417 AP180 N-terminal homology (ANTH) domain
IPR013809 Epsin-like, N-terminal

PFAM

PF01417
PF07651

PRINTS

PIRSF

SMART

SM00273

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A7Z035

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

538540

UniGene

Bt.51195

RefSeq

NP_001098887

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC153233

GenPept

AAI53234