InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPTBN4

Summary

InnateDB Protein

IDBP-766023.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPTBN4

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000469242

InnateDB Gene

IDBG-51618 (SPTBN4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0019902	phosphatase binding
GO:0030506	ankyrin binding
GO:0030507	spectrin binding

Biological Process

GO:0002028	regulation of sodium ion transport
GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007605	sensory perception of sound
GO:0007628	adult walking behavior
GO:0010459	negative regulation of heart rate
GO:0016192	vesicle-mediated transport
GO:0019226	transmission of nerve impulse
GO:0021952	central nervous system projection neuron axonogenesis
GO:0033135	regulation of peptidyl-serine phosphorylation
GO:0045162	clustering of voltage-gated sodium channels
GO:0051693	actin filament capping
GO:0061337	cardiac conduction
GO:0090002	establishment of protein localization to plasma membrane

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005912	adherens junction
GO:0008091	spectrin
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0016605	PML body
GO:0033268	node of Ranvier
GO:0043025	neuronal cell body
GO:0043194	axon initial segment
GO:0043203	axon hillock
GO:0070852	cell body fiber

Protein Structure and Domains

PDB ID

InterPro

IPR001605 Pleckstrin homology domain, spectrin-type
IPR001715 Calponin homology domain
IPR001849 Pleckstrin homology domain
IPR002017 Spectrin repeat
IPR016343 Spectrin, beta subunit
IPR018159 Spectrin/alpha-actinin
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM

PF00307
PF00169
PF00435
PF11971

PRINTS

PR00683

PIRSF

PIRSF002297

SMART

SM00033
SM00233
SM00150

TIGRFAMs

Post-translational Modifications

Modification

Cross-References