InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CXCR2

Summary

InnateDB Protein

IDBP-80806.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCR2

Protein Name

chemokine (C-X-C motif) receptor 2

Synonyms

CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB;

Species

Homo sapiens

Ensembl Protein

ENSP00000319635

InnateDB Gene

IDBG-80804 (CXCR2)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004918	interleukin-8 receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016494	C-X-C chemokine receptor activity
GO:0019959	interleukin-8 binding

Biological Process

GO:0002407	dendritic cell chemotaxis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0030593	neutrophil chemotaxis
GO:0031623	receptor internalization
GO:0038112	interleukin-8-mediated signaling pathway
GO:0042119	neutrophil activation
GO:0045087	innate immune response (InnateDB)
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042629	mast cell granule

Protein Structure and Domains

PDB ID

InterPro

IPR000057 CXC chemokine receptor 2
IPR000174 CXC chemokine receptor 1/2
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR001277 CXC chemokine receptor 4
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00573
PR00427
PR00237
PR00657
PR00645

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P25025