InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC46A1

Summary

InnateDB Protein

IDBP-810379.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC46A1

Protein Name

solute carrier family 46 (folate transporter), member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000480703

InnateDB Gene

IDBG-36627 (SLC46A1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005542	folic acid binding
GO:0008517	folic acid transporter activity
GO:0015232	heme transporter activity
GO:0015350	methotrexate transporter activity

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006879	cellular iron ion homeostasis
GO:0015884	folic acid transport
GO:0015886	heme transport
GO:0044281	small molecule metabolic process
GO:0046655	folic acid metabolic process
GO:0051958	methotrexate transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane

Protein Structure and Domains

PDB ID

InterPro

IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96NT5

PhosphoSite