InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VAMP3

Summary

InnateDB Protein

IDBP-88200.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAMP3

Protein Name

vesicle-associated membrane protein 3 (cellubrevin)

Synonyms

CEB;

Species

Homo sapiens

Ensembl Protein

ENSP00000054666

InnateDB Gene

IDBG-88198 (VAMP3)

Protein Structure

UniProt Annotation

Function

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269PubMed:18195106}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding
GO:0017075	syntaxin-1 binding

Biological Process

GO:0001921	positive regulation of receptor recycling
GO:0006461	protein complex assembly
GO:0006887	exocytosis
GO:0006904	vesicle docking involved in exocytosis
GO:0016192	vesicle-mediated transport
GO:0017156	calcium ion-dependent exocytosis
GO:0034446	substrate adhesion-dependent cell spreading
GO:0035493	SNARE complex assembly
GO:0042147	retrograde transport, endosome to Golgi
GO:0043001	Golgi to plasma membrane protein transport
GO:0061025	membrane fusion

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030054	cell junction
GO:0030136	clathrin-coated vesicle
GO:0030141	secretory granule
GO:0030665	clathrin-coated vesicle membrane
GO:0031201	SNARE complex
GO:0031410	cytoplasmic vesicle
GO:0043005	neuron projection
GO:0043229	intracellular organelle
GO:0043231	intracellular membrane-bounded organelle
GO:0045202	synapse
GO:0055037	recycling endosome