Version 5.4
Homo sapiens Protein: CTRC
Summary
InnateDB Protein IDBP-90820.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTRC
Protein Name chymotrypsin C (caldecrin)
Synonyms CLCR; ELA4;
Species Homo sapiens
Ensembl Protein ENSP00000365116
InnateDB Gene IDBG-90818 (CTRC)
Protein Structure
UniProt Annotation
Function Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity. {ECO:0000269PubMed:23430245}.
Subcellular Localization
Disease Associations Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. {ECO:0000269PubMed:18059268, ECO:0000269PubMed:18172691, ECO:0000269PubMed:22580415, ECO:0000269PubMed:22942235}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Loss-of-function CTRC variants predispose to pancreatitis by diminishing its protective trypsin-degrading activity (PubMed:18059268). They cause loss of function by one or more of three mechanisms: reduced secretion, catalytic defect and increased degradation by trypsin (PubMed:22942235). {ECO:0000269PubMed:18059268, ECO:0000269PubMed:22942235}.
Tissue Specificity Pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99895
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 11330
UniGene Hs.631869
RefSeq NP_009203
HUGO HGNC:2523
OMIM 601405
CCDS CCDS156
HPRD 03242
IMGT
EMBL AK289447 AL031283 BC015118 CH471167 S82198 Y13697
GenPept AAB47104 AAH15118 BAF82136 CAA74031 CAB77355 EAW51726

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca