InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2G2D

Summary

InnateDB Protein

IDBP-92828.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G2D

Protein Name

phospholipase A2, group IID

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000364246

InnateDB Gene

IDBG-92826 (PLA2G2D)

Protein Structure

UniProt Annotation

Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Broadly expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004623	phospholipase A2 activity
GO:0005509	calcium ion binding

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006954	inflammatory response
GO:0016042	lipid catabolic process
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036149	phosphatidylinositol acyl-chain remodeling
GO:0036150	phosphatidylserine acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process