InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUPL2

Summary

InnateDB Protein

IDBP-9600.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUPL2

Protein Name

nucleoporin like 2

Synonyms

CG1; hCG1; NLP_1; NLP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000258742

InnateDB Gene

IDBG-9598 (NUPL2)

Protein Structure

UniProt Annotation

Function

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. {ECO:0000269PubMed:10610322, ECO:0000269PubMed:16000379}.

Subcellular Localization

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Excluded from the nucleolus.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:10358091}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005049	nuclear export signal receptor activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0006611	protein export from nucleus
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0051028	mRNA transport
GO:0055085	transmembrane transport