Version 5.4
Homo sapiens Gene: CYR61
Summary
InnateDB Gene IDBG-100054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYR61
Gene Name cysteine-rich, angiogenic inducer, 61
Synonyms CCN1; GIG1; IGFBP10
Species Homo sapiens
Ensembl Gene ENSG00000142871
Encoded Proteins
IDBP-386348
cysteine-rich, angiogenic inducer, 61
IDBP-806617
cysteine-rich, angiogenic inducer, 61
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:85580761-85583962
Strand Forward strand
Band p22.3
Transcripts
ENST00000451137 ENSP00000398736
ENST00000480413
ENST00000617517 ENSP00000479537
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
GO:0008201 heparin binding
GO:0050840 extracellular matrix binding
Biological Process
GO:0001558 regulation of cell growth
GO:0001649 osteoblast differentiation
GO:0001934 positive regulation of protein phosphorylation
GO:0002041 intussusceptive angiogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003278 apoptotic process involved in heart morphogenesis
GO:0003281 ventricular septum development
GO:0006935 chemotaxis
GO:0007155 cell adhesion
GO:0008283 cell proliferation
GO:0009653 anatomical structure morphogenesis
GO:0010518 positive regulation of phospholipase activity
GO:0010811 positive regulation of cell-substrate adhesion
GO:0016337 single organismal cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0030513 positive regulation of BMP signaling pathway
GO:0033690 positive regulation of osteoblast proliferation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044319 wound healing, spreading of cells
GO:0045597 positive regulation of cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060413 atrial septum morphogenesis
GO:0060591 chondroblast differentiation
GO:0060710 chorio-allantoic fusion
GO:0060716 labyrinthine layer blood vessel development
GO:0061036 positive regulation of cartilage development
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0072593 reactive oxygen species metabolic process
GO:2000304 positive regulation of ceramide biosynthetic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028195
View Gene Order
ENSBTAG00000009844
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
integrin2_pathway
Beta2 integrin cell surface interactions
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
ap1_pathway
AP-1 transcription factor network
integrin3_pathway
Beta3 integrin cell surface interactions
rhoa_pathway
RhoA signaling pathway
integrin5_pathway
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.705639 Hs.8867
RefSeq NM_001554
HUGO
OMIM
CCDS CCDS706
HPRD 09089
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca