Version 5.4
Homo sapiens Gene: GBP3
Summary
InnateDB Gene IDBG-100156.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GBP3
Gene Name guanylate binding protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000117226
Encoded Proteins
IDBP-100160
guanylate binding protein 3
IDBP-100162
guanylate binding protein 3
IDBP-386548
guanylate binding protein 3
IDBP-598424
guanylate binding protein 3
IDBP-721825
IDBP-721576
IDBP-722568
IDBP-722102
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:89006666-89022894
Strand Reverse strand
Band p22.2
Transcripts
ENST00000370482
ENST00000370481 ENSP00000359512
ENST00000235878 ENSP00000235878
ENST00000445969 ENSP00000415087
ENST00000489444 ENSP00000437168
ENST00000461384 ENSP00000454978
ENST00000493594 ENSP00000456449
ENST00000475853
ENST00000564665 ENSP00000455317
ENST00000564037
ENST00000568006 ENSP00000455156
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0051607 defense response to virus
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_25078
Interferon gamma signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.600022 Hs.720167
RefSeq NM_018284
HUGO
OMIM
CCDS CCDS717
HPRD 02683
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca