Homo sapiens Gene: GBP3
Summary
InnateDB Gene IDBG-100156.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GBP3
Gene Name guanylate binding protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000117226
Encoded Proteins
guanylate binding protein 3
guanylate binding protein 3
guanylate binding protein 3
guanylate binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:89006666-89022894
Strand Reverse strand
Band p22.2
Transcripts
ENST00000370482
ENST00000370481 ENSP00000359512
ENST00000235878 ENSP00000235878
ENST00000445969 ENSP00000415087
ENST00000489444 ENSP00000437168
ENST00000461384 ENSP00000454978
ENST00000493594 ENSP00000456449
ENST00000475853
ENST00000564665 ENSP00000455317
ENST00000564037
ENST00000568006 ENSP00000455156
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0051607 defense response to virus
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
Interferon gamma signaling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Cross-References
SwissProt
TrEMBL F6SPX6
UniProt Splice Variant
Entrez Gene 2635
UniGene Hs.600022 Hs.720167
RefSeq NM_018284
HUGO HGNC:4184
OMIM 600413
CCDS CCDS717
HPRD 02683
IMGT
EMBL AL139416 AL160008
GenPept
RNA Seq Atlas 2635