InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VAV3

Summary

InnateDB Gene

IDBG-100649.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAV3

Gene Name

vav 3 guanine nucleotide exchange factor

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000134215

Encoded Proteins

IDBP-100651

vav 3 guanine nucleotide exchange factor

IDBP-387387

vav 3 guanine nucleotide exchange factor

IDBP-593163

vav 3 guanine nucleotide exchange factor

IDBP-602222

vav 3 guanine nucleotide exchange factor

IDBP-601059

vav 3 guanine nucleotide exchange factor

IDBP-594031

vav 3 guanine nucleotide exchange factor

IDBP-593078

vav 3 guanine nucleotide exchange factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:107571160-107965144

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000370056	ENSP00000359073
ENST00000343258
ENST00000415432	ENSP00000394897
ENST00000479977
ENST00000469325
ENST00000490388	ENSP00000433559
ENST00000527011	ENSP00000432540
ENST00000529413	ENSP00000432865
ENST00000525460
ENST00000529033
ENST00000525231	ENSP00000434944
ENST00000533398
ENST00000529809	ENSP00000431544
ENST00000524574
ENST00000530671

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0006906	vesicle fusion
GO:0006974	cellular response to DNA damage stimulus
GO:0007229	integrin-mediated signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007596	blood coagulation
GO:0009967	positive regulation of signal transduction
GO:0016477	cell migration
GO:0030031	cell projection assembly
GO:0030032	lamellipodium assembly
GO:0030168	platelet activation
GO:0030593	neutrophil chemotaxis
GO:0030890	positive regulation of B cell proliferation
GO:0032314	regulation of Rac GTPase activity
GO:0032319	regulation of Rho GTPase activity
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0043087	regulation of GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087	innate immune response
GO:0045785	positive regulation of cell adhesion
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050853	B cell receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway