Version 5.4
Homo sapiens Gene: GPSM2
Summary
InnateDB Gene IDBG-100725.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPSM2
Gene Name G-protein signaling modulator 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000121957
Encoded Proteins
IDBP-100729
G-protein signaling modulator 2
IDBP-294374
G-protein signaling modulator 2
IDBP-387458
G-protein signaling modulator 2
IDBP-387459
G-protein signaling modulator 2
IDBP-387460
G-protein signaling modulator 2
IDBP-387463
G-protein signaling modulator 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).[provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:108875350-108934545
Strand Forward strand
Band p13.3
Transcripts
ENST00000264126 ENSP00000264126
ENST00000406462 ENSP00000385510
ENST00000435987 ENSP00000408664
ENST00000435475 ENSP00000401948
ENST00000446797 ENSP00000392138
ENST00000441735 ENSP00000390629
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005092 GDP-dissociation inhibitor activity
GO:0005515 protein binding
GO:0030695 GTPase regulator activity
GO:0042802 identical protein binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0050790 regulation of catalytic activity
GO:0060487 lung epithelial cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005938 cell cortex
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027883
View Gene Order
ENSBTAG00000017124
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_013296
HUGO
OMIM
CCDS CCDS792
HPRD 06609
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca