Version 5.4
| Homo sapiens Gene: KCNA3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-100997.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | KCNA3 | ||||||||||||||||||
| Gene Name | potassium voltage-gated channel, shaker-related subfamily, member 3 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000177272 | ||||||||||||||||||
| Encoded Proteins |
potassium voltage-gated channel, shaker-related subfamily, member 3
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:110672465-110675033 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p13.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Voltage gated Potassium channels pathway
Neuronal System pathway
Potassium Channels pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P22001 | ||||||||||||||||||
| TrEMBL | B2RA23 Q6P2D3 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 3738 | ||||||||||||||||||
| UniGene | Hs.169948 | ||||||||||||||||||
| RefSeq | NM_002232 | ||||||||||||||||||
| HUGO | HGNC:6221 | ||||||||||||||||||
| OMIM | 176263 | ||||||||||||||||||
| CCDS | CCDS828 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AK314009 AL365361 BC035059 BC064595 CH471122 L23499 M38217 M55515 M85217 | ||||||||||||||||||
| GenPept | AAA36425 AAA59457 AAB88073 AAC31761 AAH35059 AAH64595 BAG36720 CAH71983 EAW56457 EAW56458 | ||||||||||||||||||
| RNA Seq Atlas | 3738 | ||||||||||||||||||