Version 5.4
Homo sapiens Gene: CHIA
Summary
InnateDB Gene IDBG-101035.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHIA
Gene Name chitinase, acidic
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134216
Encoded Proteins
IDBP-101037
chitinase, acidic
IDBP-101039
chitinase, acidic
IDBP-101041
chitinase, acidic
IDBP-101043
chitinase, acidic
IDBP-387669
chitinase, acidic
IDBP-387673
chitinase, acidic
IDBP-387674
chitinase, acidic
IDBP-583628
chitinase, acidic
IDBP-600768
chitinase, acidic
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:111290862-111320566
Strand Forward strand
Band p13.2
Transcripts
ENST00000353665 ENSP00000338970
ENST00000369740 ENSP00000358755
ENST00000343320 ENSP00000341828
ENST00000352594 ENSP00000271312
ENST00000422815 ENSP00000387671
ENST00000430615 ENSP00000391132
ENST00000451398 ENSP00000390476
ENST00000483391 ENSP00000436946
ENST00000477918
ENST00000489524 ENSP00000433309
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003796 lysozyme activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568 chitinase activity
GO:0008061 chitin binding
GO:0019900 kinase binding
GO:0030246 carbohydrate binding
Biological Process
GO:0000272 polysaccharide catabolic process
GO:0001101 response to acid
GO:0002532 production of molecular mediator involved in inflammatory response
GO:0005975 carbohydrate metabolic process
GO:0006030 chitin metabolic process
GO:0006032 chitin catabolic process
GO:0006037 cell wall chitin metabolic process
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0007586 digestion
GO:0009620 response to fungus
GO:0090197 positive regulation of chemokine secretion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062778
View Gene Order
ENSBTAG00000000259
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.128814
RefSeq NM_001040623 NM_001258001 NM_001258002 NM_001258003 NM_001258004 NM_001258005 NM_021797 NM_201653 XM_006710577
HUGO
OMIM
CCDS CCDS41368 CCDS58017 CCDS832
HPRD 09355
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca