InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRIM33

Summary

InnateDB Gene

IDBG-101286.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM33

Gene Name

tripartite motif containing 33

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000197323

Encoded Proteins

IDBP-101288

tripartite motif containing 33

IDBP-101290

tripartite motif containing 33

IDBP-387837

tripartite motif containing 33

IDBP-387838

tripartite motif containing 33

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:114392777-114511160

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000358465	ENSP00000351250
ENST00000369543	ENSP00000358556
ENST00000450349	ENSP00000412077
ENST00000448034	ENSP00000402333
ENST00000492227
ENST00000478032
ENST00000476908

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	63 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0070410	co-SMAD binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression
GO:0016567	protein ubiquitination
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated