Homo sapiens Gene: TSHB
Summary
InnateDB Gene IDBG-101335.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSHB
Gene Name thyroid stimulating hormone, beta
Synonyms TSH-B; TSH-BETA;
Species Homo sapiens
Ensembl Gene ENSG00000134200
Encoded Proteins
thyroid stimulating hormone, beta
thyroid stimulating hormone, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene result in congenital hypothyroidism.[provided by RefSeq, Nov 2009]
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto\'s thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:115029824-115034309
Strand Forward strand
Band p13.2
Transcripts
ENST00000256592 ENSP00000256592
ENST00000369517 ENSP00000358530
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0009653 anatomical structure morphogenesis
GO:0016486 peptide hormone processing
GO:0033189 response to vitamin A
GO:0043627 response to estrogen
GO:0044267 cellular protein metabolic process
GO:0051592 response to calcium ion
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TSH pathway
REACTOME
G alpha (s) signalling events pathway
Glycoprotein hormones pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Amine-derived hormones pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Metabolism of proteins pathway
Metabolism of amino acids and derivatives pathway
Peptide hormone biosynthesis pathway
Thyroxine biosynthesis pathway
Hormone ligand-binding receptors pathway
GPCR ligand binding pathway
Metabolism pathway
Peptide hormone metabolism pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Autoimmune thyroid disease pathway
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P01222
TrEMBL
UniProt Splice Variant
Entrez Gene 7252
UniGene
RefSeq NM_000549 NM_001277991
HUGO HGNC:12372
OMIM 188540
CCDS CCDS880
HPRD
IMGT
EMBL AL109660 BC069298 M21024 M23670 M23671 M25164 S70587 X02866 X02867
GenPept AAA36782 AAA61235 AAB05845 AAB30828 AAH69298 CAA26618 CAA26619 CAI22270
RNA Seq Atlas 7252