InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TSHB

Summary

InnateDB Gene

IDBG-101335.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSHB

Gene Name

thyroid stimulating hormone, beta

Synonyms

TSH-B; TSH-BETA

Species

Homo sapiens

Ensembl Gene

ENSG00000134200

Encoded Proteins

IDBP-101337

thyroid stimulating hormone, beta

IDBP-101339

thyroid stimulating hormone, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene result in congenital hypothyroidism.[provided by RefSeq, Nov 2009]
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto\'s thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:115029824-115034309

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000256592	ENSP00000256592
ENST00000369517	ENSP00000358530

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0009653	anatomical structure morphogenesis
GO:0016486	peptide hormone processing
GO:0033189	response to vitamin A
GO:0043627	response to estrogen
GO:0044267	cellular protein metabolic process
GO:0051592	response to calcium ion