InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP1A1

Summary

InnateDB Gene

IDBG-101377.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP1A1

Gene Name

ATPase, Na+/K+ transporting, alpha 1 polypeptide

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000163399

Encoded Proteins

IDBP-101379

ATPase, Na+/K+ transporting, alpha 1 polypeptide

IDBP-101381

ATPase, Na+/K+ transporting, alpha 1 polypeptide

IDBP-101385

ATPase, Na+/K+ transporting, alpha 1 polypeptide

IDBP-387878

ATPase, Na+/K+ transporting, alpha 1 polypeptide

IDBP-387883

ATPase, Na+/K+ transporting, alpha 1 polypeptide

IDBP-600567

ATPase, Na+/K+ transporting, alpha 1 polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:116372668-116410261

Strand

Forward strand

Band

p13.1

Transcripts

ENST00000369496	ENSP00000358508
ENST00000295598	ENSP00000295598
ENST00000369494	ENSP00000358506
ENST00000418797	ENSP00000400124
ENST00000440951	ENSP00000396236
ENST00000488733
ENST00000463382
ENST00000491156
ENST00000479960
ENST00000495965
ENST00000537345	ENSP00000445306

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016791	phosphatase activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0030506	ankyrin binding
GO:0030955	potassium ion binding
GO:0031402	sodium ion binding
GO:0043531	ADP binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0046872	metal ion binding
GO:0051087	chaperone binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0002028	regulation of sodium ion transport
GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0008217	regulation of blood pressure
GO:0010107	potassium ion import
GO:0015672	monovalent inorganic cation transport
GO:0016311	dephosphorylation
GO:0031947	negative regulation of glucocorticoid biosynthetic process
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042493	response to drug
GO:0045822	negative regulation of heart contraction
GO:0045823	positive regulation of heart contraction
GO:0045989	positive regulation of striated muscle contraction
GO:0055085	transmembrane transport
GO:0060081	membrane hyperpolarization
GO:0071260	cellular response to mechanical stimulus
GO:0086004	regulation of cardiac muscle cell contraction

Cellular Component

GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0005901	caveola
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030315	T-tubule
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000033161

View Gene Order

ENSBTAG00000001246

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

NetPath_11

TCR pathway

NetPath_23

TSH pathway

REACTOME

REACT_25149

Ion transport by P-type ATPases pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

hsa04260

Cardiac muscle contraction pathway

hsa04960

Aldosterone-regulated sodium reabsorption pathway

hsa04964

Proximal tubule bicarbonate reclamation pathway

hsa04971

Gastric acid secretion pathway

hsa04972

Pancreatic secretion pathway

hsa04970

Salivary secretion pathway

hsa04976

Bile secretion pathway

hsa04974

Protein digestion and absorption pathway

hsa04973

Carbohydrate digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

P05023

TrEMBL

Q5TC01 Q5TC02 Q5TC05

UniProt Splice Variant

Entrez Gene

476

UniGene

Hs.371889 Hs.738062

RefSeq

NM_000701 NM_001160233 NM_001160234 XM_006710655

HUGO

HGNC:799

OMIM

182310

CCDS

CCDS53351 CCDS53352 CCDS887

HPRD

IMGT

EMBL

AK295095 AK296362 AK314777 AL136376 BC001330 BC003077 BC050359 CH471122 D00099 J03007 L76938 M16793 M16794 M27572 M27579 M30309 M30310 U16798 X03757 X04297

GenPept

AAA35573 AAA35574 AAA51801 AAA51803 AAA92713 AAC50131 AAD56251 AAD56252 AAH01330 AAH03077 AAH50359 BAA00061 BAG37313 BAH11971 BAH12332 CAA27390 CAA27840 EAW56644

RNA Seq Atlas

476