Homo sapiens Gene: CD2
Summary
InnateDB Gene IDBG-101417.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD2
Gene Name CD2 molecule
Synonyms LFA-2; SRBC; T11;
Species Homo sapiens
Ensembl Gene ENSG00000116824
Encoded Proteins
CD2 molecule
CD2 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]
CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95%% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:116754385-116769228
Strand Forward strand
Band p13.1
Transcripts
ENST00000369478 ENSP00000358490
ENST00000369477 ENSP00000358489
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001766 membrane raft polarization
GO:0006915 apoptotic process
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007596 blood coagulation
GO:0016337 single organismal cell-cell adhesion
GO:0030101 natural killer cell activation
GO:0030887 positive regulation of myeloid dendritic cell activation
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034113 heterotypic cell-cell adhesion
GO:0042110 T cell activation
GO:0045580 regulation of T cell differentiation
GO:0050900 leukocyte migration
GO:1902715 positive regulation of interferon-gamma secretion
GO:2000484 positive regulation of interleukin-8 secretion
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0009897 external side of plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0046658 anchored component of plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
TCR pathway
REACTOME
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Hematopoietic cell lineage pathway
INOH
PID BIOCARTA
Ras-independent pathway in nk cell-mediated cytotoxicity [Biocarta view]
Stathmin and breast cancer resistance to antimicrotubule agents [Biocarta view]
PID NCI
Cross-References
SwissProt P06729
TrEMBL Q53F96
UniProt Splice Variant
Entrez Gene 914
UniGene
RefSeq NM_001767
HUGO HGNC:1639
OMIM 186990
CCDS CCDS889
HPRD 01750
IMGT
EMBL AK223393 AK313614 AL135798 BC033583 CH471122 M14362 M16336 M16445 M19798 M19800 M19802 M19804 M19806 X07871 X07872 X07873 X07874
GenPept AAA35571 AAA51738 AAA51946 AAA53095 AAH33583 BAD97113 BAG36377 CAA30721 CAC14840 EAW56661
RNA Seq Atlas 914