Homo sapiens Gene: PRKAB2
Summary
InnateDB Gene IDBG-101806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKAB2
Gene Name protein kinase, AMP-activated, beta 2 non-catalytic subunit
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131791
Encoded Proteins
protein kinase, AMP-activated, beta 2 non-catalytic subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:147155106-147172550
Strand Reverse strand
Band q21.1
Transcripts
ENST00000254101 ENSP00000254101
ENST00000496858
ENST00000474939
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.
Experimentally validated
Total 92 [view]
Protein-Protein 89 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004679 AMP-activated protein kinase activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006468 protein phosphorylation
GO:0006633 fatty acid biosynthetic process
GO:0006853 carnitine shuttle
GO:0007050 cell cycle arrest
GO:0007165 signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0042304 regulation of fatty acid biosynthetic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0061024 membrane organization
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0031588 AMP-activated protein kinase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Leptin pathway
REACTOME
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Integration of energy metabolism pathway
Organelle biogenesis and maintenance pathway
Metabolism of lipids and lipoproteins pathway
PKB-mediated events pathway
mTOR signalling pathway
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Mitochondrial biogenesis pathway
Signal Transduction pathway
PI3K Cascade pathway
IRS-mediated signalling pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
Regulation of Rheb GTPase activity by AMPK pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IRS-related events pathway
Translocation of GLUT4 to the plasma membrane pathway
AMPK inhibits chREBP transcriptional activation activity pathway
IGF1R signaling cascade pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Signaling by Insulin receptor pathway
Metabolism pathway
Regulation of AMPK activity via LKB1 pathway
Membrane Trafficking pathway
KEGG
Circadian rhythm pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Hypertrophic cardiomyopathy (HCM) pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
Chrebp regulation by carbohydrates and camp [Biocarta view]
Reversal of insulin resistance by leptin [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.50732 Hs.598065
RefSeq NM_005399
HUGO
OMIM
CCDS CCDS925
HPRD 04117
IMGT
EMBL
GenPept
RNA Seq Atlas