InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRKAB2

Summary

InnateDB Gene

IDBG-101806.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKAB2

Gene Name

protein kinase, AMP-activated, beta 2 non-catalytic subunit

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000131791

Encoded Proteins

IDBP-101808

protein kinase, AMP-activated, beta 2 non-catalytic subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:147155106-147172550

Strand

Reverse strand

Band

q21.1

Transcripts

ENST00000254101	ENSP00000254101
ENST00000496858
ENST00000474939

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.

Experimentally validated
Total	92 [view]
Protein-Protein	89 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004679	AMP-activated protein kinase activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006468	protein phosphorylation
GO:0006633	fatty acid biosynthetic process
GO:0006853	carnitine shuttle
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0008286	insulin receptor signaling pathway
GO:0042304	regulation of fatty acid biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0061024	membrane organization