Homo sapiens Gene: MCL1
Summary
InnateDB Gene IDBG-102145.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCL1
Gene Name myeloid cell leukemia sequence 1 (BCL2-related)
Synonyms bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; TM;
Species Homo sapiens
Ensembl Gene ENSG00000143384
Encoded Proteins
myeloid cell leukemia sequence 1 (BCL2-related)
myeloid cell leukemia sequence 1 (BCL2-related)
myeloid cell leukemia 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:150574551-150579738
Strand Reverse strand
Band q21.2
Transcripts
ENST00000369026 ENSP00000358022
ENST00000307940 ENSP00000309973
ENST00000464132
ENST00000620947 ENSP00000477624
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 87 [view]
Protein-Protein 82 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015266 protein channel activity
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051434 BH3 domain binding
Biological Process
GO:0001709 cell fate determination
GO:0007275 multicellular organismal development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637 apoptotic mitochondrial changes
GO:0019725 cellular homeostasis
GO:0034097 response to cytokine
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0071806 protein transmembrane transport
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194 execution phase of apoptosis
GO:1900118 negative regulation of execution phase of apoptosis
GO:2000811 negative regulation of anoikis
GO:2001020 regulation of response to DNA damage stimulus
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0097136 Bcl-2 family protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Direct p53 effectors
E2F transcription factor network
HIF-1-alpha transcription factor network
IL6-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001197320 NM_021960 NM_182763
HUGO
OMIM
CCDS CCDS72909 CCDS956 CCDS957
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas