Homo sapiens Gene: CTSK
Summary
InnateDB Gene IDBG-102192.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSK
Gene Name cathepsin K
Synonyms CTS02; CTSO; CTSO1; CTSO2; PKND; PYCD;
Species Homo sapiens
Ensembl Gene ENSG00000143387
Encoded Proteins
cathepsin K
cathepsin K
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CTSK is a cathepsins, which are key modulators of cell death and inflammatory responses.
Cleavage of CAMP by cathepsins CTSS and CTSK impairs its antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus.
Entrez Gene
Summary The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:150796208-150808323
Strand Reverse strand
Band q21.3
Transcripts
ENST00000271651 ENSP00000271651
ENST00000443913 ENSP00000405083
ENST00000480670
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 6 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0004197 cysteine-type endopeptidase activity
GO:0005518 collagen binding
GO:0008234 cysteine-type peptidase activity
GO:0043394 proteoglycan binding
Biological Process
GO:0001957 intramembranous ossification
GO:0002224 toll-like receptor signaling pathway
GO:0006508 proteolysis
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045453 bone resorption
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0036021 endolysosome lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MHC class II antigen presentation pathway
Extracellular matrix organization pathway
Innate Immune System pathway
Degradation of the extracellular matrix pathway
Activation of Matrix Metalloproteinases pathway
Toll-Like Receptors Cascades pathway
Adaptive Immune System pathway
Immune System pathway
Trafficking and processing of endosomal TLR pathway
Collagen degradation pathway
KEGG
Lysosome pathway
Osteoclast differentiation pathway
Toll-like receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P43235
TrEMBL
UniProt Splice Variant
Entrez Gene 1513
UniGene Hs.632466 Hs.729184
RefSeq NM_000396
HUGO HGNC:2536
OMIM 601105
CCDS CCDS969
HPRD 03064
IMGT
EMBL AL355860 AL356292 BC016058 CH471121 CR541675 S79895 U13665 U20280 X82153
GenPept AAA65233 AAA95998 AAB35521 AAH16058 CAA57649 CAG46476 CAI12795 CAI13649 EAW53516
RNA Seq Atlas 1513