InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CTSK

Summary

InnateDB Gene

IDBG-102192.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSK

Gene Name

cathepsin K

Synonyms

CTS02; CTSO; CTSO1; CTSO2; PKND; PYCD

Species

Homo sapiens

Ensembl Gene

ENSG00000143387

Encoded Proteins

IDBP-102196

cathepsin K

IDBP-388392

cathepsin K

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18762176

CTSK is a cathepsins, which are key modulators of cell death and inflammatory responses.

PMID 25884905

Cleavage of CAMP by cathepsins CTSS and CTSK impairs its antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus.

Entrez Gene

Summary

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:150796208-150808323

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000271651	ENSP00000271651
ENST00000443913	ENSP00000405083
ENST00000480670

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	6 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0004197	cysteine-type endopeptidase activity
GO:0005518	collagen binding
GO:0008234	cysteine-type peptidase activity
GO:0043394	proteoglycan binding

Biological Process

GO:0001957	intramembranous ossification
GO:0002224	toll-like receptor signaling pathway
GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045453	bone resorption
GO:0051603	proteolysis involved in cellular protein catabolic process