Version 5.4
Homo sapiens Gene: S100A6
Summary
InnateDB Gene IDBG-102681.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S100A6
Gene Name S100 calcium binding protein A6
Synonyms 2A9; 5B10; CABP; CACY; PRA
Species Homo sapiens
Ensembl Gene ENSG00000197956
Encoded Proteins
IDBP-102683
S100 calcium binding protein A6
IDBP-102685
S100 calcium binding protein A6
IDBP-812731
S100 calcium binding protein A6
IDBP-812733
S100 calcium binding protein A6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153534599-153536244
Strand Reverse strand
Band q21.3
Transcripts
ENST00000368720 ENSP00000357709
ENST00000368719 ENSP00000357708
ENST00000496817 ENSP00000473589
ENST00000462776 ENSP00000473547
ENST00000462951
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005523 tropomyosin binding
GO:0008270 zinc ion binding
GO:0015075 ion transmembrane transporter activity
GO:0042803 protein homodimerization activity
GO:0044548 S100 protein binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0007165 signal transduction
GO:0007409 axonogenesis
GO:0034220 ion transmembrane transport
GO:0048146 positive regulation of fibroblast proliferation
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000001025
View Gene Order
Cross-References
SwissProt
TrEMBL R4GN98
UniProt Splice Variant
Entrez Gene 6277
UniGene
RefSeq NM_014624
HUGO HGNC:10496
OMIM 114110
CCDS CCDS1040
HPRD
IMGT
EMBL BX470102
GenPept
RNA Seq Atlas 6277

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca