Homo sapiens Gene: SHC1
InnateDB Gene IDBG-103007.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHC1
Gene Name SHC (Src homology 2 domain containing) transforming protein 1
Synonyms SHC; SHCA;
Species Homo sapiens
Ensembl Gene ENSG00000160691
Encoded Proteins
SHC (Src homology 2 domain containing) transforming protein 1
SHC (Src homology 2 domain containing) transforming protein 1
SHC (Src homology 2 domain containing) transforming protein 1
SHC (Src homology 2 domain containing) transforming protein 1
SHC (Src homology 2 domain containing) transforming protein 1
SHC (Src homology 2 domain containing) transforming protein 1
SHC (Src homology 2 domain containing) transforming protein 1
SHC (Src homology 2 domain containing) transforming protein 1
SHC (Src homology 2 domain containing) transforming protein 1
SHC (Src homology 2 domain containing) transforming protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:154962298-154974395
Strand Reverse strand
Band q21.3
ENST00000368453 ENSP00000357438
ENST00000368450 ENSP00000357435
ENST00000368449 ENSP00000357434
ENST00000368445 ENSP00000357430
ENST00000366442 ENSP00000396162
ENST00000448116 ENSP00000401303
ENST00000444664 ENSP00000396333
ENST00000414115 ENSP00000404908
ENST00000444179 ENSP00000398864
ENST00000412170 ENSP00000398441
Number of Interactions This gene and/or its encoded proteins are associated with 311 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated
Total 311 [view]
Protein-Protein 309 [view]
Protein-DNA 2 [view]
Protein-RNA 0
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004713 protein tyrosine kinase activity
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0030971 receptor tyrosine kinase binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0007265 Ras protein signal transduction
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0016337 single organismal cell-cell adhesion
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030168 platelet activation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031532 actin cytoskeleton reorganization
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0040008 regulation of growth
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response
GO:0045740 positive regulation of DNA replication
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050900 leukocyte migration
Cellular Component
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070435 Shc-EGFR complex
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Alpha6Beta4Integrin pathway
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
IL-7 pathway
IL9 pathway
Leptin pathway
TSH pathway
TSLP pathway
Prolactin pathway
Oncostatin_M pathway
SHC-related events pathway
IRE1alpha activates chaperones pathway
Unfolded Protein Response (UPR) pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
SHC1 events in ERBB4 signaling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Signaling by constitutively active EGFR pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signaling by EGFR pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Signaling by ERBB4 pathway
XBP1(S) activates chaperone genes pathway
SHC-related events triggered by IGF1R pathway
SHC activation pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Tie2 Signaling pathway
Integrin alphaIIb beta3 signaling pathway
SHC1 events in EGFR signaling pathway
Metabolism of proteins pathway
SHC-mediated signalling pathway
Immune System pathway
Insulin receptor signalling cascade pathway
GPVI-mediated activation cascade pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Platelet Aggregation (Plug Formation) pathway
SHC1 events in ERBB2 signaling pathway
IGF1R signaling cascade pathway
Signal attenuation pathway
Signalling to RAS pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
G beta:gamma signalling through PI3Kgamma pathway
Cell surface interactions at the vascular wall pathway
Disease pathway
Hemostasis pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Focal adhesion pathway
Natural killer cell mediated cytotoxicity pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
Bacterial invasion of epithelial cells pathway
Glioma pathway
Chronic myeloid leukemia pathway
IGF1 signaling pathway pathway
NGF signaling pathway pathway
PDGF signaling pathway pathway
Integrin signaling pathway pathway
IL-5 signaling pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
Il 2 signaling pathway [Biocarta view]
Il 3 signaling pathway [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Il 6 signaling pathway [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Transcription factor creb and its extracellular signals [Biocarta view]
Role of erbb2 in signal transduction and oncology [Biocarta view]
Epo signaling pathway [Biocarta view]
Bcr signaling pathway [Biocarta view]
Integrin signaling pathway [Biocarta view]
Map kinase inactivation of smrt corepressor [Biocarta view]
Trka receptor signaling pathway [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Il 4 signaling pathway [Biocarta view]
Pdgf signaling pathway [Biocarta view]
Multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation [Biocarta view]
Insulin signaling pathway [Biocarta view]
Mcalpain and friends in cell motility [Biocarta view]
Nerve growth factor pathway (ngf) [Biocarta view]
Calcium signaling by hbx of hepatitis b virus [Biocarta view]
Growth hormone signaling pathway [Biocarta view]
Phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway [Biocarta view]
Tpo signaling pathway [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Sprouty regulation of tyrosine kinase signals [Biocarta view]
Role of erk5 in neuronal survival pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Egf signaling pathway [Biocarta view]
Igf-1 signaling pathway [Biocarta view]
Erk1/erk2 mapk signaling pathway [Biocarta view]
Pten dependent cell cycle arrest and apoptosis [Biocarta view]
The igf-1 receptor and longevity [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
Trk receptor signaling mediated by PI3K and PLC-gamma
TCR signaling in na´ve CD8+ T cells
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
IL2-mediated signaling events
ErbB4 signaling events
TCR signaling in na´ve CD4+ T cells
Internalization of ErbB1
VEGFR3 signaling in lymphatic endothelium
Signaling events mediated by PTP1B
a6b1 and a6b4 Integrin signaling
IGF1 pathway
EPO signaling pathway
EPHB forward signaling
Neurotrophic factor-mediated Trk receptor signaling
p75(NTR)-mediated signaling
FGF signaling pathway
BCR signaling pathway
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
EGFR-dependent Endothelin signaling events
Signaling events mediated by TCPTP
IL4-mediated signaling events
ErbB2/ErbB3 signaling events
IL3-mediated signaling events
Plasma membrane estrogen receptor signaling
Signaling events regulated by Ret tyrosine kinase
TGF-beta receptor signaling
SHP2 signaling
IL2 signaling events mediated by STAT5
GMCSF-mediated signaling events
EPHA2 forward signaling
Fc-epsilon receptor I signaling in mast cells
PDGFR-alpha signaling pathway
IL2 signaling events mediated by PI3K
PDGFR-beta signaling pathway
Insulin Pathway
SwissProt P29353
TrEMBL B4DL02 Q5T181 Q5T182 Q5T187 Q5T188 Q8NFT0 Q8NFT1 X6R6D0
UniProt Splice Variant
Entrez Gene 6464
UniGene Hs.433795 Hs.743646
RefSeq NM_001130040 NM_001130041 NM_001202859 NM_003029 NM_183001
OMIM 600560
CCDS CCDS1076 CCDS30881 CCDS44233 CCDS44234
EMBL AB451255 AB451379 AF455141 AK292143 AK296786 AK315842 AL451085 BC014158 BC033925 CH471121 U73377 X68148 Y09847
GenPept AAB49972 AAH14158 AAH33925 AAM61859 AAM61860 BAF84832 BAF98733 BAG59364 BAG70069 BAG70193 CAA48251 CAA70977 CAI13248 CAI13249 CAI13250 CAI13251 CAI13254 EAW53168 EAW53169 EAW53170 EAW53171
RNA Seq Atlas 6464