Homo sapiens Gene: DAP3
Summary
InnateDB Gene IDBG-103299.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAP3
Gene Name death associated protein 3
Synonyms bMRP-10; DAP-3; MRP-S29; MRPS29;
Species Homo sapiens
Ensembl Gene ENSG00000132676
Encoded Proteins
death associated protein 3
death associated protein 3
death associated protein 3
death associated protein 3
death associated protein 3
death associated protein 3
death associated protein 3
death associated protein 3
death associated protein 3
death associated protein 3
death associated protein 3
death associated protein 3
death associated protein 3
death associated protein 3
death associated protein 3
death associated protein 3
death associated protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75%% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155687960-155739010
Strand Forward strand
Band q22
Transcripts
ENST00000368336 ENSP00000357320
ENST00000343043 ENSP00000341692
ENST00000421487 ENSP00000412605
ENST00000461479
ENST00000471642 ENSP00000476592
ENST00000471214 ENSP00000476899
ENST00000479076
ENST00000496863
ENST00000465375 ENSP00000476889
ENST00000462002
ENST00000470830 ENSP00000476816
ENST00000497826 ENSP00000476840
ENST00000463575 ENSP00000476291
ENST00000471523
ENST00000479151 ENSP00000477265
ENST00000466384
ENST00000462978
ENST00000477394 ENSP00000476558
ENST00000475056 ENSP00000476624
ENST00000490249 ENSP00000477139
ENST00000497433
ENST00000463295 ENSP00000477453
ENST00000476444
ENST00000491777 ENSP00000476706
ENST00000535183 ENSP00000445003
ENST00000608852 ENSP00000477025
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
Experimentally validated
Total 47 [view]
Protein-Protein 45 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006915 apoptotic process
GO:0008637 apoptotic mitochondrial changes
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005761 mitochondrial ribosome
GO:0015935 small ribosomal subunit
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
TRAIL signaling pathway
Cross-References
SwissProt P51398
TrEMBL E2JL21 V9GYF7 V9GYL9
UniProt Splice Variant
Entrez Gene 7818
UniGene Hs.516746 Hs.707165 Hs.732416
RefSeq NM_033657 NM_001199849 NM_004632 NM_001199850 NM_001199851 XM_005245480
HUGO HGNC:2673
OMIM 602074
CCDS CCDS1120 CCDS55647 CCDS55646
HPRD 03646
IMGT
EMBL AB061210 AK293117 AK298201 AK302281 AL162734 BC107487 BC107488 BT019494 CH471121 CR749790 U18321 X83544
GenPept AAA57443 AAI07488 AAI07489 AAV38301 BAB54960 BAF85806 BAG60471 BAG63624 CAA58535 CAH18651 CAH71647 EAW53044 EAW53045 EAW53047 EAW53048 EAW53049 EAW53051
RNA Seq Atlas 7818