Homo sapiens Gene: SH2D2A
Summary
InnateDB Gene IDBG-103627.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH2D2A
Gene Name SH2 domain containing 2A
Synonyms F2771; SCAP; TSAD; VRAP;
Species Homo sapiens
Ensembl Gene ENSG00000027869
Encoded Proteins
SH2 domain containing 2A
SH2 domain containing 2A
SH2 domain containing 2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156806243-156816862
Strand Reverse strand
Band q23.1
Transcripts
ENST00000368199 ENSP00000357182
ENST00000368198 ENSP00000357181
ENST00000392306 ENSP00000376123
ENST00000468744
ENST00000486350
ENST00000495306
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0001525 angiogenesis
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0009967 positive regulation of signal transduction
GO:0030154 cell differentiation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TCR pathway
REACTOME
Signaling by VEGF pathway
Signal Transduction pathway
VEGFA-VEGFR2 Pathway pathway
KEGG
VEGF signaling pathway pathway
INOH
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
ErbB1 downstream signaling
Signaling events mediated by VEGFR1 and VEGFR2
Cross-References
SwissProt Q9NP31
TrEMBL
UniProt Splice Variant
Entrez Gene 9047
UniGene Hs.103527
RefSeq NM_001161444 NM_003975 XM_006711615 NM_001161443 NM_001161442 NM_001161441
HUGO HGNC:10821
OMIM 604514
CCDS CCDS1159 CCDS53380 CCDS53381
HPRD 05152
IMGT
EMBL AF051325 AF097744 AF106072 AJ000553 AK222737 AL158169 AL590666 AY763100 BC012107
GenPept AAC99298 AAF43260 AAF69027 AAH12107 AAV34675 BAD96457 CAA04185 CAH70007 CAH70008 CAI16336 CAI16337
RNA Seq Atlas 9047