Version 5.4
Homo sapiens Gene: PEA15
Summary
InnateDB Gene IDBG-104008.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEA15
Gene Name phosphoprotein enriched in astrocytes 15
Synonyms HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; PED
Species Homo sapiens
Ensembl Gene ENSG00000162734
Encoded Proteins
IDBP-104010
phosphoprotein enriched in astrocytes 15
IDBP-104012
phosphoprotein enriched in astrocytes 15
IDBP-104014
phosphoprotein enriched in astrocytes 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. [provided by RefSeq, Sep 2011]
This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:160205337-160215376
Strand Forward strand
Band q23.2
Transcripts
ENST00000360472 ENSP00000353660
ENST00000368077 ENSP00000357056
ENST00000368076 ENSP00000357055
ENST00000488858
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006915 apoptotic process
GO:0008643 carbohydrate transport
GO:0042981 regulation of apoptotic process
GO:0043278 response to morphine
GO:0046325 negative regulation of glucose import
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005737 cytoplasm
GO:0005875 microtubule associated complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000013698
View Gene Order
ENSBTAG00000005793
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p73pathway
p73 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517216 Hs.705879
RefSeq NM_001297576 NM_003768 XM_005245564 XM_006711598 XM_006711599
HUGO
OMIM
CCDS CCDS1199 CCDS72954
HPRD 04579
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca