Homo sapiens Gene: PEA15
Summary
InnateDB Gene IDBG-104008.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEA15
Gene Name phosphoprotein enriched in astrocytes 15
Synonyms HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; PED;
Species Homo sapiens
Ensembl Gene ENSG00000162734
Encoded Proteins
phosphoprotein enriched in astrocytes 15
phosphoprotein enriched in astrocytes 15
phosphoprotein enriched in astrocytes 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. [provided by RefSeq, Sep 2011]
This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:160205337-160215376
Strand Forward strand
Band q23.2
Transcripts
ENST00000360472 ENSP00000353660
ENST00000368077 ENSP00000357056
ENST00000368076 ENSP00000357055
ENST00000488858
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006915 apoptotic process
GO:0008643 carbohydrate transport
GO:0042981 regulation of apoptotic process
GO:0043278 response to morphine
GO:0046325 negative regulation of glucose import
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005737 cytoplasm
GO:0005875 microtubule associated complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
p73 transcription factor network
Cross-References
SwissProt Q15121
TrEMBL B1AKZ3 B1AKZ4 B1AKZ5
UniProt Splice Variant
Entrez Gene 8682
UniGene Hs.517216 Hs.705879
RefSeq NM_001297576 NM_003768 XM_005245564 XM_006711598 XM_006711599
HUGO HGNC:8822
OMIM 603434
CCDS CCDS1199 CCDS72954
HPRD
IMGT
EMBL AF153273 AF153274 AK095879 AK311762 AL121987 AL139011 BC002426 BC022554 BT007252 CH471121 X86809 Y13736
GenPept AAD56775 AAH02426 AAH22554 AAP35916 BAG34705 BAG53155 CAA60499 CAA74076 EAW52733 EAW52734 EAW52735
RNA Seq Atlas 8682