InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: COPA

Summary

InnateDB Gene

IDBG-104029.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COPA

Gene Name

coatomer protein complex, subunit alpha

Synonyms

HEP-COP

Species

Homo sapiens

Ensembl Gene

ENSG00000122218

Encoded Proteins

IDBP-104031

coatomer protein complex, subunit alpha

IDBP-104033

coatomer protein complex, subunit alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:160289273-160343400

Strand

Reverse strand

Band

q23.2

Transcripts

ENST00000368069	ENSP00000357048
ENST00000241704	ENSP00000241704
ENST00000481522
ENST00000481040
ENST00000545284
ENST00000541366
ENST00000545266

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	70 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0016192	vesicle-mediated transport
GO:0030157	pancreatic juice secretion
GO:0048205	COPI coating of Golgi vesicle
GO:0061024	membrane organization

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030117	membrane coat
GO:0030126	COPI vesicle coat
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026553

View Gene Order

ENSBTAG00000004333

Not yet available

Pathways

NETPATH

REACTOME

REACT_11096

COPI Mediated Transport pathway

REACT_11208

Golgi to ER Retrograde Transport pathway

REACT_11123

Membrane Trafficking pathway

KEGG

INOH

PID NCI

arf_3pathway

Arf1 pathway

cmyb_pathway

C-MYB transcription factor network

Cross-References

SwissProt

P53621

TrEMBL

UniProt Splice Variant

Entrez Gene

1314

UniGene

Hs.162121 Hs.656374

RefSeq

NM_004371 NM_001098398

HUGO

HGNC:2230

OMIM

601924

CCDS

CCDS1202 CCDS41424

HPRD

03564

IMGT

EMBL

AL445230 AL513282 BC038447 CH471121 U24105

GenPept

AAB70879 AAH38447 CAI12454 CAI12455 CAI15004 CAI15005 EAW52723 EAW52725

RNA Seq Atlas

1314