Version 5.4
Homo sapiens Gene: USF1
Summary
InnateDB Gene IDBG-104152.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USF1
Gene Name upstream transcription factor 1
Synonyms bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI; UEF
Species Homo sapiens
Ensembl Gene ENSG00000158773
Encoded Proteins
IDBP-104154
upstream transcription factor 1
IDBP-104156
upstream transcription factor 1
IDBP-104158
upstream transcription factor 1
IDBP-602482
upstream transcription factor 1
IDBP-597410
upstream transcription factor 1
IDBP-596354
upstream transcription factor 1
IDBP-598648
upstream transcription factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:161039251-161045977
Strand Reverse strand
Band q23.3
Transcripts
ENST00000368021 ENSP00000357000
ENST00000368020 ENSP00000356999
ENST00000368019 ENSP00000356998
ENST00000472217
ENST00000473969 ENSP00000435671
ENST00000496363
ENST00000491629
ENST00000528768 ENSP00000433041
ENST00000531842 ENSP00000435005
ENST00000534633 ENSP00000432533
ENST00000529476
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 65 [view]
Protein-Protein 50 [view]
Protein-DNA 15 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0001666 response to hypoxia
GO:0006006 glucose metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0009411 response to UV
GO:0019086 late viral transcription
GO:0032869 cellular response to insulin stimulus
GO:0042593 glucose homeostasis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045990 carbon catabolite regulation of transcription
GO:0051918 negative regulation of fibrinolysis
GO:0055088 lipid homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026641
View Gene Order
ENSBTAG00000017873
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.414880
RefSeq NM_001276373 NM_007122 NM_207005
HUGO
OMIM
CCDS CCDS1214
HPRD 01880
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca