InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KIFAP3

Summary

InnateDB Gene

IDBG-104737.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIFAP3

Gene Name

kinesin-associated protein 3

Synonyms

dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP; Smg-GDS

Species

Homo sapiens

Ensembl Gene

ENSG00000075945

Encoded Proteins

IDBP-104739

kinesin-associated protein 3

IDBP-104741

kinesin-associated protein 3

IDBP-104745

kinesin-associated protein 3

IDBP-602451

kinesin-associated protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 \'Armadillo\' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:169921326-170085208

Strand

Reverse strand

Band

q24.2

Transcripts

ENST00000367767	ENSP00000356741
ENST00000367765	ENSP00000356739
ENST00000361580	ENSP00000354560
ENST00000474292
ENST00000490550
ENST00000538366	ENSP00000444622

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0019894	kinesin binding

Biological Process

GO:0006461	protein complex assembly
GO:0007017	microtubule-based process
GO:0007018	microtubule-based movement
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0008104	protein localization
GO:0008285	negative regulation of cell proliferation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043066	negative regulation of apoptotic process
GO:0046587	positive regulation of calcium-dependent cell-cell adhesion
GO:0061024	membrane organization
GO:0072383	plus-end-directed vesicle transport along microtubule

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0005783	endoplasmic reticulum
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005876	spindle microtubule
GO:0015630	microtubule cytoskeleton
GO:0016939	kinesin II complex
GO:0030990	intraciliary transport particle
GO:0070062	extracellular vesicular exosome