Homo sapiens Gene: KIFAP3
Summary
InnateDB Gene IDBG-104737.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIFAP3
Gene Name kinesin-associated protein 3
Synonyms dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP; Smg-GDS;
Species Homo sapiens
Ensembl Gene ENSG00000075945
Encoded Proteins
kinesin-associated protein 3
kinesin-associated protein 3
kinesin-associated protein 3
kinesin-associated protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 \'Armadillo\' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:169921326-170085208
Strand Reverse strand
Band q24.2
Transcripts
ENST00000367767 ENSP00000356741
ENST00000367765 ENSP00000356739
ENST00000361580 ENSP00000354560
ENST00000474292
ENST00000490550
ENST00000538366 ENSP00000444622
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0019894 kinesin binding
Biological Process
GO:0006461 protein complex assembly
GO:0007017 microtubule-based process
GO:0007018 microtubule-based movement
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0008104 protein localization
GO:0008285 negative regulation of cell proliferation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043066 negative regulation of apoptotic process
GO:0046587 positive regulation of calcium-dependent cell-cell adhesion
GO:0061024 membrane organization
GO:0072383 plus-end-directed vesicle transport along microtubule
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005783 endoplasmic reticulum
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0015630 microtubule cytoskeleton
GO:0016939 kinesin II complex
GO:0030990 intraciliary transport particle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MHC class II antigen presentation pathway
Kinesins pathway
Adaptive Immune System pathway
Immune System pathway
Translocation of GLUT4 to the plasma membrane pathway
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
Membrane Trafficking pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.433442 Hs.706155
RefSeq NM_001204514 NM_001204516 NM_001204517 NM_014970
HUGO
OMIM
CCDS CCDS1288 CCDS55659 CCDS55660 CCDS55661
HPRD 03499
IMGT
EMBL
GenPept
RNA Seq Atlas