InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GLUL

Summary

InnateDB Gene

IDBG-105226.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLUL

Gene Name

glutamate-ammonia ligase

Synonyms

GLNS; GS; PIG43; PIG59

Species

Homo sapiens

Ensembl Gene

ENSG00000135821

Encoded Proteins

IDBP-105228

glutamate-ammonia ligase

IDBP-105230

glutamate-ammonia ligase

IDBP-105232

glutamate-ammonia ligase

IDBP-389787

glutamate-ammonia ligase

IDBP-807264

glutamate-ammonia ligase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:182381704-182392206

Strand

Reverse strand

Band

q25.3

Transcripts

ENST00000331872	ENSP00000356537
ENST00000311223	ENSP00000307900
ENST00000339526	ENSP00000344958
ENST00000417584	ENSP00000398320
ENST00000491322
ENST00000463851
ENST00000461447
ENST00000484996
ENST00000489818
ENST00000475808
ENST00000480604
ENST00000462444
ENST00000621524	ENSP00000481855

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	25 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004351	glutamate decarboxylase activity
GO:0004356	glutamate-ammonia ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016595	glutamate binding
GO:0030145	manganese ion binding
GO:0042802	identical protein binding
GO:0045503	dynein light chain binding

Biological Process

GO:0001504	neurotransmitter uptake
GO:0006536	glutamate metabolic process
GO:0006538	glutamate catabolic process
GO:0006542	glutamine biosynthetic process
GO:0006807	nitrogen compound metabolic process
GO:0007268	synaptic transmission
GO:0008283	cell proliferation
GO:0008652	cellular amino acid biosynthetic process
GO:0009267	cellular response to starvation
GO:0009749	response to glucose
GO:0032024	positive regulation of insulin secretion
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051260	protein homooligomerization
GO:0051968	positive regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005791	rough endoplasmic reticulum
GO:0005829	cytosol
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0043204	perikaryon
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0043679	axon terminus
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome
GO:0097386	glial cell projection