Homo sapiens Gene: GLUL
Summary
InnateDB Gene IDBG-105226.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLUL
Gene Name glutamate-ammonia ligase
Synonyms GLNS; GS; PIG43; PIG59;
Species Homo sapiens
Ensembl Gene ENSG00000135821
Encoded Proteins
glutamate-ammonia ligase
glutamate-ammonia ligase
glutamate-ammonia ligase
glutamate-ammonia ligase
glutamate-ammonia ligase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:182381704-182392206
Strand Reverse strand
Band q25.3
Transcripts
ENST00000331872 ENSP00000356537
ENST00000311223 ENSP00000307900
ENST00000339526 ENSP00000344958
ENST00000417584 ENSP00000398320
ENST00000491322
ENST00000463851
ENST00000461447
ENST00000484996
ENST00000489818
ENST00000475808
ENST00000480604
ENST00000462444
ENST00000621524 ENSP00000481855
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 25 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004351 glutamate decarboxylase activity
GO:0004356 glutamate-ammonia ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016595 glutamate binding
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0045503 dynein light chain binding
Biological Process
GO:0001504 neurotransmitter uptake
GO:0006536 glutamate metabolic process
GO:0006538 glutamate catabolic process
GO:0006542 glutamine biosynthetic process
GO:0006807 nitrogen compound metabolic process
GO:0007268 synaptic transmission
GO:0008283 cell proliferation
GO:0008652 cellular amino acid biosynthetic process
GO:0009267 cellular response to starvation
GO:0009749 response to glucose
GO:0032024 positive regulation of insulin secretion
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051260 protein homooligomerization
GO:0051968 positive regulation of synaptic transmission, glutamatergic
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043204 perikaryon
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
GO:0043679 axon terminus
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
GO:0097386 glial cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
Neuronal System pathway
Neurotransmitter uptake and Metabolism In Glial Cells pathway
Amino acid synthesis and interconversion (transamination) pathway
Metabolism of amino acids and derivatives pathway
Astrocytic Glutamate-Glutamine Uptake And Metabolism pathway
Transmission across Chemical Synapses pathway
Metabolism pathway
KEGG
Alanine, aspartate and glutamate metabolism pathway
Arginine and proline metabolism pathway
Glyoxylate and dicarboxylate metabolism pathway
Nitrogen metabolism pathway
INOH
Glutamate Glutamine metabolism pathway
Arginine Proline metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518525 Hs.559602 Hs.708180
RefSeq NM_001033044 NM_001033056 NM_002065 XM_006711278
HUGO
OMIM
CCDS CCDS1344
HPRD 00701
IMGT
EMBL
GenPept
RNA Seq Atlas