Homo sapiens Gene: RGS1
Summary
InnateDB Gene IDBG-105443.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS1
Gene Name regulator of G-protein signaling 1
Synonyms 1R20; BL34; HEL-S-87; IER1; IR20;
Species Homo sapiens
Ensembl Gene ENSG00000090104
Encoded Proteins
regulator of G-protein signaling 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:192575727-192580031
Strand Forward strand
Band q31.2
Transcripts
ENST00000367459 ENSP00000356429
ENST00000474373
ENST00000469578 ENSP00000464323
ENST00000462589
ENST00000498352
ENST00000583155
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005516 calmodulin binding
Biological Process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
CXCR4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.603797 Hs.75256
RefSeq NM_002922
HUGO
OMIM
CCDS CCDS1375
HPRD 15968
IMGT
EMBL
GenPept
RNA Seq Atlas