Version 5.4
Homo sapiens Gene: RGS2
Summary
InnateDB Gene IDBG-105451.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS2
Gene Name regulator of G-protein signaling 2, 24kDa
Synonyms G0S8
Species Homo sapiens
Ensembl Gene ENSG00000116741
Encoded Proteins
IDBP-105453
regulator of G-protein signaling 2, 24kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22120521
RGS2 negatively regulates NOX1 expression and consequently inhibits reactive oxygen species production in TLR-mediated innate immune responses. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22120521
[Mus musculus] Rgs2 negatively regulates Nox1 expression and consequently inhibits reactive oxygen species production in TLR-mediate innate immune responses.
Entrez Gene
Summary Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:192809039-192812283
Strand Forward strand
Band q31.2
Transcripts
ENST00000235382 ENSP00000235382
ENST00000483295
ENST00000464302
ENST00000487236
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 101 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 101 [view]
Protein-Protein 100 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0006417 regulation of translation
GO:0007049 cell cycle
GO:0007283 spermatogenesis
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0010519 negative regulation of phospholipase activity
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0031116 positive regulation of microtubule polymerization
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043407 negative regulation of MAP kinase activity
GO:0043547 positive regulation of GTPase activity
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0045087 innate immune response (InnateDB)
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0050873 brown fat cell differentiation
GO:0055119 relaxation of cardiac muscle
GO:0060087 relaxation of vascular smooth muscle
GO:0060452 positive regulation of cardiac muscle contraction
GO:0071877 regulation of adrenergic receptor signaling pathway
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026360
View Gene Order
ENSBTAG00000034366
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002923
HUGO
OMIM
CCDS CCDS1377
HPRD 02917
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca