Homo sapiens Gene: ATP6V0C
Summary
InnateDB Gene IDBG-10561.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP6V0C
Gene Name ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Synonyms ATP6C; ATP6L; ATPL; VATL; Vma3; VPPC;
Species Homo sapiens
Ensembl Gene ENSG00000185883
Encoded Proteins
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:2513726-2520223
Strand Forward strand
Band p13.3
Transcripts
ENST00000330398 ENSP00000329757
ENST00000568562 ENSP00000454597
ENST00000565223 ENSP00000457782
ENST00000564973 ENSP00000454868
ENST00000618152 ENSP00000481778
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0031625 ubiquitin protein ligase binding
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006879 cellular iron ion homeostasis
GO:0008286 insulin receptor signaling pathway
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0016032 viral process
GO:0030177 positive regulation of Wnt signaling pathway
GO:0033572 transferrin transport
GO:0051701 interaction with host
GO:0055085 transmembrane transport
GO:0090382 phagosome maturation
Cellular Component
GO:0005765 lysosomal membrane
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0030670 phagocytic vesicle membrane
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0033179 proton-transporting V-type ATPase, V0 domain
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Iron uptake and transport pathway
Insulin receptor recycling pathway
Signal Transduction pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Signaling by Insulin receptor pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
KEGG
Oxidative phosphorylation pathway
Lysosome pathway
Phagosome pathway
Collecting duct acid secretion pathway
Vibrio cholerae infection pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H3BNI4
UniProt Splice Variant
Entrez Gene 527
UniGene
RefSeq NM_001198569 NM_001694
HUGO HGNC:855
OMIM 108745
CCDS CCDS10470
HPRD 00162
IMGT
EMBL AC093525 CH471112
GenPept EAW85501
RNA Seq Atlas 527