Homo sapiens Gene: KISS1
Summary
InnateDB Gene IDBG-106029.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KISS1
Gene Name KiSS-1 metastasis-suppressor
Synonyms HH13; KiSS-1;
Species Homo sapiens
Ensembl Gene ENSG00000170498
Encoded Proteins
KiSS-1 metastasis-suppressor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:204190341-204196486
Strand Reverse strand
Band q32.1
Transcripts
ENST00000367194 ENSP00000356162
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007010 cytoskeleton organization
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002256
HUGO
OMIM
CCDS CCDS41454
HPRD 04475
IMGT
EMBL
GenPept
RNA Seq Atlas