Version 5.4
Homo sapiens Gene: ELK4
Summary
InnateDB Gene IDBG-106151.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELK4
Gene Name ELK4, ETS-domain protein (SRF accessory protein 1)
Synonyms SAP1
Species Homo sapiens
Ensembl Gene ENSG00000158711
Encoded Proteins
IDBP-106153
ELK4, ETS-domain protein (SRF accessory protein 1)
IDBP-106157
ELK4, ETS-domain protein (SRF accessory protein 1)
IDBP-812508
ELK4, ETS-domain protein (SRF accessory protein 1)
IDBP-812505
ELK4, ETS-domain protein (SRF accessory protein 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:205597556-205631962
Strand Reverse strand
Band q32.1
Transcripts
ENST00000357992 ENSP00000350681
ENST00000289703 ENSP00000289703
ENST00000468523 ENSP00000484946
ENST00000616704 ENSP00000483628
ENST00000617725
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001047 core promoter binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0030154 cell differentiation
GO:0070932 histone H3 deacetylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026436
View Gene Order
ENSBTAG00000004953
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_5
ID pathway
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
INOH website
PDGF signaling pathway pathway
PID NCI
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 2005
UniGene
RefSeq NM_001973 NM_021795
HUGO HGNC:3326
OMIM 600246
CCDS CCDS1456 CCDS1457
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 2005

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca