InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CR2

Summary

InnateDB Gene

IDBG-106349.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CR2

Gene Name

complement component (3d/Epstein Barr virus) receptor 2

Synonyms

C3DR; CD21; CR; CVID7; SLEB9

Species

Homo sapiens

Ensembl Gene

ENSG00000117322

Encoded Proteins

IDBP-106351

complement component (3d/Epstein Barr virus) receptor 2

IDBP-106353

complement component (3d/Epstein Barr virus) receptor 2

IDBP-106355

complement component (3d/Epstein Barr virus) receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20558730

CR2 (CD21) is a cell membrane receptor, with 15 or 16 extracellular short consensus repeats (SCRs), that promotes B lymphocyte responses and bridges innate and acquired immunity.

Entrez Gene

Summary

This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:207454230-207489895

Strand

Forward strand

Band

q32.2

Transcripts

ENST00000367057	ENSP00000356024
ENST00000367058	ENSP00000356025
ENST00000367059	ENSP00000356026
ENST00000479186
ENST00000485707
ENST00000475194

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	12 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001848	complement binding
GO:0003677	DNA binding
GO:0004872	receptor activity
GO:0004875	complement receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0002430	complement receptor mediated signaling pathway
GO:0006955	immune response
GO:0006958	complement activation, classical pathway
GO:0030183	B cell differentiation
GO:0042100	B cell proliferation
GO:0042113	B cell activation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000026616

View Gene Order

Pathways

NETPATH

NetPath_12

BCR pathway

REACTOME

KEGG

hsa04640

Hematopoietic cell lineage pathway

hsa04610

Complement and coagulation cascades pathway

hsa04662

B cell receptor signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.445757 Hs.609955

RefSeq

NM_001006658 NM_001877

HUGO

OMIM

CCDS

CCDS1478 CCDS31007

HPRD

00399

IMGT

EMBL

GenPept

RNA Seq Atlas