Version 5.4
Homo sapiens Gene: PLXNA2
Summary
InnateDB Gene IDBG-106408.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLXNA2
Gene Name plexin A2
Synonyms OCT; PLXN2
Species Homo sapiens
Ensembl Gene ENSG00000076356
Encoded Proteins
IDBP-106410
plexin A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:208022242-208244320
Strand Reverse strand
Band q32.2
Transcripts
ENST00000367033 ENSP00000356000
ENST00000483048
ENST00000480053
ENST00000463510
ENST00000460870
ENST00000486969
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0017154 semaphorin receptor activity
Biological Process
GO:0001756 somitogenesis
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0021915 neural tube development
GO:0021935 cerebellar granule cell precursor tangential migration
GO:0030334 regulation of cell migration
GO:0051642 centrosome localization
GO:0060037 pharyngeal system development
GO:0060174 limb bud formation
GO:0071526 semaphorin-plexin signaling pathway
Cellular Component
GO:0002116 semaphorin receptor complex
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000026640
View Gene Order
Pathways
NETPATH
REACTOME
REACT_19199
CRMPs in Sema3A signaling pathway
REACT_19236
Sema3A PAK dependent Axon repulsion pathway
REACT_19200
Other semaphorin interactions pathway
REACT_19279
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.497626
RefSeq NM_025179
HUGO
OMIM
CCDS CCDS31013
HPRD 03033
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca