Homo sapiens Gene: CENPF
Summary
InnateDB Gene IDBG-106648.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CENPF
Gene Name centromere protein F, 350/400kDa (mitosin)
Synonyms CENF; hcp-1; PRO1779;
Species Homo sapiens
Ensembl Gene ENSG00000117724
Encoded Proteins
centromere protein F, 350/400kDa (mitosin)
centromere protein F, 350/400kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:214603195-214664588
Strand Forward strand
Band q41
Transcripts
ENST00000366955 ENSP00000355922
ENST00000464322
ENST00000495259
ENST00000467765
ENST00000469862
ENST00000614578 ENSP00000478221
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 22 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0042803 protein homodimerization activity
GO:0045502 dynein binding
Biological Process
GO:0000085 mitotic G2 phase
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000087 mitotic M phase
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007094 mitotic spindle assembly checkpoint
GO:0007517 muscle organ development
GO:0008283 cell proliferation
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0015031 protein transport
GO:0016202 regulation of striated muscle tissue development
GO:0030154 cell differentiation
GO:0042493 response to drug
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051310 metaphase plate congression
GO:0051382 kinetochore assembly
GO:0051726 regulation of cell cycle
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000785 chromatin
GO:0000922 spindle pole
GO:0000940 condensed chromosome outer kinetochore
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0016363 nuclear matrix
GO:0030496 midbody
GO:0045120 pronucleus
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
Polo-like kinase mediated events pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
FOXM1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.497741 Hs.596369 Hs.601409 Hs.610772 Hs.695109
RefSeq NM_016343
HUGO
OMIM
CCDS CCDS31023
HPRD 02582
IMGT
EMBL
GenPept
RNA Seq Atlas