InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CENPF

Summary

InnateDB Gene

IDBG-106648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CENPF

Gene Name

centromere protein F, 350/400kDa (mitosin)

Synonyms

CENF; hcp-1; PRO1779

Species

Homo sapiens

Ensembl Gene

ENSG00000117724

Encoded Proteins

IDBP-106650

centromere protein F, 350/400kDa (mitosin)

IDBP-809454

centromere protein F, 350/400kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:214603195-214664588

Strand

Forward strand

Band

q41

Transcripts

ENST00000366955	ENSP00000355922
ENST00000464322
ENST00000495259
ENST00000467765
ENST00000469862
ENST00000614578	ENSP00000478221

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	22 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0045502	dynein binding

Biological Process

GO:0000085	mitotic G2 phase
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000087	mitotic M phase
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007094	mitotic spindle assembly checkpoint
GO:0007517	muscle organ development
GO:0008283	cell proliferation
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0015031	protein transport
GO:0016202	regulation of striated muscle tissue development
GO:0030154	cell differentiation
GO:0042493	response to drug
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051310	metaphase plate congression
GO:0051382	kinetochore assembly
GO:0051726	regulation of cell cycle

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000785	chromatin
GO:0000922	spindle pole
GO:0000940	condensed chromosome outer kinetochore
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005829	cytosol
GO:0016363	nuclear matrix
GO:0030496	midbody
GO:0045120	pronucleus
GO:0048471	perinuclear region of cytoplasm