Homo sapiens Gene: PYCR2
Summary
InnateDB Gene IDBG-106980.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PYCR2
Gene Name pyrroline-5-carboxylate reductase family, member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143811
Encoded Proteins
pyrroline-5-carboxylate reductase family, member 2
pyrroline-5-carboxylate reductase family, member 2
pyrroline-5-carboxylate reductase family, member 2
pyrroline-5-carboxylate reductase family, member 2
pyrroline-5-carboxylate reductase family, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:225919877-225924340
Strand Reverse strand
Band q42.12
Transcripts
ENST00000343818 ENSP00000342502
ENST00000446534
ENST00000478402
ENST00000466127
ENST00000489681 ENSP00000482614
ENST00000472798 ENSP00000480779
ENST00000467298
ENST00000612039 ENSP00000478165
ENST00000612651 ENSP00000482845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004735 pyrroline-5-carboxylate reductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0006561 proline biosynthetic process
GO:0046168 glycerol-3-phosphate catabolic process
GO:0055114 oxidation-reduction process
GO:0055129 L-proline biosynthetic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Arginine and proline metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96C36
TrEMBL A0A024R3Q9 B3KMB7
UniProt Splice Variant
Entrez Gene 29920
UniGene Hs.654718
RefSeq NM_013328 NM_001271681
HUGO HGNC:30262
OMIM
CCDS CCDS31043 CCDS73039
HPRD 17939
IMGT
EMBL AF087859 AK001508 AK291913 AL117348 BC014868 BC020553 CH471098
GenPept AAH14868 AAH20553 AAP97169 BAF84602 BAG50929 CAI21802 EAW69761 EAW69762 EAW69763 EAW69764 EAW69765
RNA Seq Atlas 102466270 29920