Version 5.4
Homo sapiens Gene: PYCR2
Summary
InnateDB Gene IDBG-106980.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PYCR2
Gene Name pyrroline-5-carboxylate reductase family, member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143811
Encoded Proteins
IDBP-106982
pyrroline-5-carboxylate reductase family, member 2
IDBP-807408
pyrroline-5-carboxylate reductase family, member 2
IDBP-807409
pyrroline-5-carboxylate reductase family, member 2
IDBP-807414
pyrroline-5-carboxylate reductase family, member 2
IDBP-807418
pyrroline-5-carboxylate reductase family, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:225919877-225924340
Strand Reverse strand
Band q42.12
Transcripts
ENST00000343818 ENSP00000342502
ENST00000446534
ENST00000478402
ENST00000466127
ENST00000489681 ENSP00000482614
ENST00000472798 ENSP00000480779
ENST00000467298
ENST00000612039 ENSP00000478165
ENST00000612651 ENSP00000482845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004735 pyrroline-5-carboxylate reductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0006561 proline biosynthetic process
GO:0046168 glycerol-3-phosphate catabolic process
GO:0055114 oxidation-reduction process
GO:0055129 L-proline biosynthetic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026520
View Gene Order
ENSBTAG00000005835
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00330
Arginine and proline metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654718
RefSeq NM_001271681 NM_013328
HUGO
OMIM
CCDS CCDS31043 CCDS73039
HPRD 17939
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca