Homo sapiens Gene: PARP1
Summary
InnateDB Gene IDBG-107034.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARP1
Gene Name poly (ADP-ribose) polymerase 1
Synonyms ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1; PARP; PARP-1; PPOL;
Species Homo sapiens
Ensembl Gene ENSG00000143799
Encoded Proteins
poly (ADP-ribose) polymerase 1
poly (ADP-ribose) polymerase 1
poly (ADP-ribose) polymerase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:226360691-226408075
Strand Reverse strand
Band q42.12
Transcripts
ENST00000366794 ENSP00000355759
ENST00000366792 ENSP00000355757
ENST00000366790 ENSP00000355755
ENST00000490921
ENST00000463968
ENST00000491816
ENST00000468608
ENST00000498787
ENST00000469663
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 294 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 295 [view]
Protein-Protein 292 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
GO:0047485 protein N-terminus binding
GO:0051287 NAD binding
GO:0070412 R-SMAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000723 telomere maintenance
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006302 double-strand break repair
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006471 protein ADP-ribosylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0010467 gene expression
GO:0016540 protein autoprocessing
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030225 macrophage differentiation
GO:0032869 cellular response to insulin stimulus
GO:0040009 regulation of growth rate
GO:0042769 DNA damage response, detection of DNA damage
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0070212 protein poly-ADP-ribosylation
GO:2000679 positive regulation of transcription regulatory region DNA binding
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0016020 membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
TWEAK pathway
Oncostatin_M pathway
REACTOME
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Generic Transcription Pathway pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
KEGG
Base excision repair pathway
INOH
PID BIOCARTA
Opposing roles of aif in apoptosis and cell survival [Biocarta view]
Induction of apoptosis through dr3 and dr4/5 death receptors [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Caspase cascade in apoptosis [Biocarta view]
PID NCI
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL Q5VX84
UniProt Splice Variant
Entrez Gene 142
UniGene Hs.177766 Hs.611340 Hs.707776
RefSeq NM_001618
HUGO HGNC:270
OMIM 173870
CCDS CCDS1554
HPRD 01435
IMGT
EMBL AL359704 AL359742
GenPept
RNA Seq Atlas 142