InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PARP1

Summary

InnateDB Gene

IDBG-107034.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PARP1

Gene Name

poly (ADP-ribose) polymerase 1

Synonyms

ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1; PARP; PARP-1; PPOL;

Species

Homo sapiens

Ensembl Gene

ENSG00000143799

Encoded Proteins

IDBP-107036

poly (ADP-ribose) polymerase 1

IDBP-107038

poly (ADP-ribose) polymerase 1

IDBP-107042

poly (ADP-ribose) polymerase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:226360691-226408075

Strand

Reverse strand

Band

q42.12

Transcripts

ENST00000366794	ENSP00000355759
ENST00000366792	ENSP00000355757
ENST00000366790	ENSP00000355755
ENST00000490921
ENST00000463968
ENST00000491816
ENST00000468608
ENST00000498787
ENST00000469663

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 294 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	295 [view]
Protein-Protein	292 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding
GO:0047485	protein N-terminus binding
GO:0051287	NAD binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000723	telomere maintenance
GO:0006259	DNA metabolic process
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006302	double-strand break repair
GO:0006351	transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006471	protein ADP-ribosylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression
GO:0016540	protein autoprocessing
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030225	macrophage differentiation
GO:0032869	cellular response to insulin stimulus
GO:0040009	regulation of growth rate
GO:0042769	DNA damage response, detection of DNA damage
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060391	positive regulation of SMAD protein import into nucleus
GO:0070212	protein poly-ADP-ribosylation
GO:2000679	positive regulation of transcription regulatory region DNA binding

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0016020	membrane
GO:0043234	protein complex