Homo sapiens Gene: ARF1
Summary
InnateDB Gene IDBG-107128.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARF1
Gene Name ADP-ribosylation factor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143761
Encoded Proteins
ADP-ribosylation factor 1
ADP-ribosylation factor 1
ADP-ribosylation factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:228082660-228099212
Strand Forward strand
Band q42.13
Transcripts
ENST00000272102 ENSP00000272102
ENST00000470670
ENST00000478424
ENST00000470558
ENST00000473949
ENST00000477451
ENST00000478336
ENST00000469235
ENST00000473546
ENST00000482962
ENST00000497165
ENST00000490705
ENST00000540651 ENSP00000442980
ENST00000541182 ENSP00000440005
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 56 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002090 regulation of receptor internalization
GO:0006184 GTP catabolic process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006878 cellular copper ion homeostasis
GO:0006886 intracellular protein transport
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0006892 post-Golgi vesicle-mediated transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation
GO:0044281 small molecule metabolic process
GO:0048205 COPI coating of Golgi vesicle
GO:0050690 regulation of defense response to virus by virus
GO:0060292 long term synaptic depression
GO:0061024 membrane organization
GO:0097061 dendritic spine organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0014069 postsynaptic density
GO:0030017 sarcomere
GO:0030054 cell junction
GO:0043005 neuron projection
GO:0045211 postsynaptic membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TSH pathway
REACTOME
MHC class II antigen presentation pathway
Metabolism of lipids and lipoproteins pathway
trans-Golgi Network Vesicle Budding pathway
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
Synthesis of PIPs at the Golgi membrane pathway
Adaptive Immune System pathway
Clathrin derived vesicle budding pathway
COPI Mediated Transport pathway
Immune System pathway
Golgi Associated Vesicle Biogenesis pathway
PI Metabolism pathway
Phospholipid metabolism pathway
Nef Mediated CD4 Down-regulation pathway
Golgi to ER Retrograde Transport pathway
HIV Infection pathway
Lysosome Vesicle Biogenesis pathway
Metabolism pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Host Interactions of HIV factors pathway
Disease pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
Vibrio cholerae infection pathway
INOH
PID BIOCARTA
Adp-ribosylation factor [Biocarta view]
Phosphoinositides and their downstream targets [Biocarta view]
PID NCI
Class I PI3K signaling events
Arf1 pathway
Signaling events mediated by VEGFR1 and VEGFR2
Arf6 downstream pathway
Cross-References
SwissProt P84077
TrEMBL A0A024R3Q3
UniProt Splice Variant
Entrez Gene 375
UniGene
RefSeq NM_001024226 NM_001024227 NM_001024228 NM_001658
HUGO HGNC:652
OMIM 103180
CCDS CCDS1565
HPRD
IMGT
EMBL AF052179 AF055002 AF493881 AL136379 BC009247 BC010429 BC011358 BT007393 CH471098 M36340 M84326 M84332
GenPept AAA35511 AAA35512 AAA35552 AAC09356 AAC28623 AAH09247 AAH10429 AAH11358 AAM12595 AAP36057 CAI23120 EAW69831 EAW69832 EAW69834 EAW69836
RNA Seq Atlas 100500810 375