Version 5.4
Homo sapiens Gene: ATP5J
Summary
InnateDB Gene IDBG-1075.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP5J
Gene Name ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
Synonyms ATP5; ATP5A; ATPM; CF6; F6
Species Homo sapiens
Ensembl Gene ENSG00000154723
Encoded Proteins
IDBP-1077
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
IDBP-229045
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
IDBP-229047
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
IDBP-229049
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
IDBP-229051
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
IDBP-229055
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
IDBP-361007
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex, required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. A pseudogene exists on chromosome Yp11.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:25716503-25735673
Strand Reverse strand
Band q21.3
Transcripts
ENST00000284971 ENSP00000284971
ENST00000400099 ENSP00000382971
ENST00000400094 ENSP00000382966
ENST00000400093 ENSP00000382965
ENST00000400090 ENSP00000382962
ENST00000400087 ENSP00000382959
ENST00000457143 ENSP00000389649
ENST00000486002
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0016887 ATPase activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006200 ATP catabolic process
GO:0015986 ATP synthesis coupled proton transport
GO:0021762 substantia nigra development
GO:0022904 respiratory electron transport chain
GO:0042776 mitochondrial ATP synthesis coupled proton transport
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022890
View Gene Order
ENSBTAG00000000605
Not yet available
Pathways
NETPATH
REACTOME
REACT_6759
Formation of ATP by chemiosmotic coupling pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa00190
Oxidative phosphorylation pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001003696 NM_001003697 NM_001003701 NM_001003703 NM_001685 XM_005260992
HUGO
OMIM
CCDS CCDS13574 CCDS46637
HPRD 04399
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca