Version 5.4
Homo sapiens Gene: CNST
Summary
InnateDB Gene IDBG-107844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNST
Gene Name consortin, connexin sorting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162852
Encoded Proteins
IDBP-107846
consortin, connexin sorting protein
IDBP-107848
consortin, connexin sorting protein
IDBP-107850
consortin, connexin sorting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:246566444-246668584
Strand Forward strand
Band q44
Transcripts
ENST00000366513 ENSP00000355470
ENST00000366512 ENSP00000355469
ENST00000366511 ENSP00000355468
ENST00000483271
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019902 phosphatase binding
GO:0071253 connexin binding
Biological Process
GO:0010923 negative regulation of phosphatase activity
GO:0042998 positive regulation of Golgi to plasma membrane protein transport
Cellular Component
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030133 transport vesicle
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038949
View Gene Order
ENSBTAG00000000511
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.368353 Hs.603722
RefSeq NM_001139459 NM_152609 XM_005273081 XM_005273082 XM_006711751
HUGO
OMIM
CCDS CCDS1628 CCDS44343
HPRD 08718
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca