Version 5.4
Homo sapiens Gene: LDB2
Summary
InnateDB Gene IDBG-10850.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LDB2
Gene Name LIM domain binding 2
Synonyms CLIM1; LDB1
Species Homo sapiens
Ensembl Gene ENSG00000169744
Encoded Proteins
IDBP-10854
LIM domain binding 2
IDBP-363767
LIM domain binding 2
IDBP-482209
LIM domain binding 2
IDBP-478291
LIM domain binding 2
IDBP-479389
LIM domain binding 2
IDBP-479743
LIM domain binding 2
IDBP-478861
LIM domain binding 2
IDBP-479060
LIM domain binding 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins (summarized by Semina et al., 1998 [PubMed 9799849]). These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes (Jurata and Gill, 1997 [PubMed 9315627]). The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 (Bach et al., 1997 [PubMed 9192866]) and Clim2/Lbd1/Nli (Agulnick et al., 1996 [PubMed 8918878]; Jurata et al., 1996 [PubMed 8876198]; Bach et al., 1997 [PubMed 9192866]) and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:16501541-16898809
Strand Reverse strand
Band p15.32
Transcripts
ENST00000304523 ENSP00000306772
ENST00000441778 ENSP00000392089
ENST00000515064 ENSP00000422552
ENST00000509803
ENST00000502640 ENSP00000423963
ENST00000507464 ENSP00000425754
ENST00000508918 ENSP00000424770
ENST00000512345 ENSP00000424676
ENST00000503153
ENST00000504886
ENST00000506732 ENSP00000421767
ENST00000503829
ENST00000508804
ENST00000513457
ENST00000510825
ENST00000504189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000989 transcription factor binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030274 LIM domain binding
Biological Process
GO:0001942 hair follicle development
GO:0010669 epithelial structure maintenance
GO:0035019 somatic stem cell maintenance
GO:0044089 positive regulation of cellular component biogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039706
View Gene Order
ENSBTAG00000014058
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.23748
RefSeq NM_001130834 NM_001290 XM_005248197 XM_005248198 XM_005248201 XM_005248202 XM_005248203 XM_006713977 XM_006713978 XM_006713980 XM_006713981 XM_006713984
HUGO
OMIM
CCDS CCDS3420 CCDS47031
HPRD 16022
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca