Homo sapiens Gene: CHN2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-10872.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CHN2 | ||||||||||||||||||||||
Gene Name | chimerin 2 | ||||||||||||||||||||||
Synonyms | ARHGAP3; BCH; CHN2-3; RHOGAP3 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000106069 | ||||||||||||||||||||||
Encoded Proteins |
chimerin (chimaerin) 2
chimerin (chimaerin) 2
chimerin (chimaerin) 2
chimerin (chimaerin) 2
chimerin (chimaerin) 2
chimerin (chimaerin) 2
chimerin (chimaerin) 2
chimerin (chimaerin) 2
chimerin (chimaerin) 2
chimerin (chimaerin) 2
chimerin (chimaerin) 2
chimerin (chimaerin) 2
chimerin (chimaerin) 2
chimerin (chimaerin) 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 7:29122274-29514328 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | p14.3 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Rho GTPase cycle pathway
Signaling by Rho GTPases pathway
Signal Transduction pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
Regulation of RAC1 activity
ErbB1 downstream signaling
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Cross-References | |||||||||||||||||||||||
SwissProt | P52757 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 644086 | ||||||||||||||||||||||
UniGene | Hs.653033 Hs.666750 Hs.734596 | ||||||||||||||||||||||
RefSeq | NM_001039936 NM_001293072 NM_001293077 NM_001293078 NM_001293081 NM_004067 | ||||||||||||||||||||||
HUGO | HGNC:1944 | ||||||||||||||||||||||
OMIM | 602857 | ||||||||||||||||||||||
CCDS | CCDS5420 | ||||||||||||||||||||||
HPRD | 04173 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC004417 AC004593 AC005232 AC007096 AC007255 AK026415 AK313021 AK316030 BC112155 CH236948 CH471073 EU732752 EU732753 EU732754 EU732758 EU732762 GQ924106 L29126 U07223 U28926 | ||||||||||||||||||||||
GenPept | AAA16836 AAA19191 AAA86528 AAC06177 AAI12156 AAS07498 ACF04989 ACF04990 ACF04991 ACF04995 ACF04999 ADK47390 BAG35856 BAH14401 EAL24205 EAW93919 | ||||||||||||||||||||||
RNA Seq Atlas | 101928168 1124 644086 | ||||||||||||||||||||||