Homo sapiens Gene: TCEB2
Summary
InnateDB Gene IDBG-10956.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCEB2
Gene Name transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
Synonyms ELOB; SIII;
Species Homo sapiens
Ensembl Gene ENSG00000103363
Encoded Proteins
transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TCEB2 is a part of Elongin BC complex, is a component of a multiprotein SOCS1 complex that attenuates JAK/STAT signaling by binding to JAK2 and inhibiting JAK2 kinase and by interacting with SOCS box, the Elongin BC complex can increase expression of the SOCS1 protein by inhibiting its degradation.
TCEB2, as a part of the Elongin B and C complex, is bound by SOCS protein for proteasomal degradation.
Entrez Gene
Summary This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:2771414-2777297
Strand Reverse strand
Band p13.3
Transcripts
ENST00000262306 ENSP00000262306
ENST00000409906 ENSP00000386652
ENST00000409477 ENSP00000387189
ENST00000494946 ENSP00000458213
ENST00000572954 ENSP00000458443
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 158 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 158 [view]
Protein-Protein 158 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003746 translation elongation factor activity
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006366 transcription from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006414 translational elongation
GO:0006461 protein complex assembly
GO:0010467 gene expression
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0045087 innate immune response (InnateDB)
GO:0050434 positive regulation of viral transcription
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0031462 Cul2-RING ubiquitin ligase complex
GO:0031466 Cul5-RING ubiquitin ligase complex
GO:0070062 extracellular vesicular exosome
GO:0070449 elongin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Cellular responses to stress pathway
Vif-mediated degradation of APOBEC3G pathway
Pausing and recovery of Tat-mediated HIV elongation pathway
Late Phase of HIV Life Cycle pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
Tat-mediated elongation of the HIV-1 transcript pathway
Tat-mediated HIV elongation arrest and recovery pathway
Formation of RNA Pol II elongation complex pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
HIV Transcription Elongation pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
Adaptive Immune System pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
RNA Polymerase II Transcription pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Cellular response to hypoxia pathway
Pausing and recovery of HIV elongation pathway
HIV Life Cycle pathway
HIV elongation arrest and recovery pathway
RNA Polymerase II Pre-transcription Events pathway
Transcription of the HIV genome pathway
RNA Polymerase II Transcription Elongation pathway
HIV Infection pathway
Class I MHC mediated antigen processing & presentation pathway
Host Interactions of HIV factors pathway
Gene Expression pathway
Disease pathway
KEGG
Ubiquitin mediated proteolysis pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
INOH
PID BIOCARTA
PID NCI
HIF-2-alpha transcription factor network
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Cross-References
SwissProt
TrEMBL B8ZZU8
UniProt Splice Variant
Entrez Gene 6923
UniGene
RefSeq NM_007108 NM_207013 XM_006720937
HUGO HGNC:11619
OMIM 600787
CCDS CCDS32374 CCDS45387
HPRD 02874
IMGT
EMBL AC092117 CH471112
GenPept EAW85473 EAW85476
RNA Seq Atlas 6923