InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TCEB2

Summary

InnateDB Gene

IDBG-10956.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCEB2

Gene Name

transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)

Synonyms

ELOB; SIII

Species

Homo sapiens

Ensembl Gene

ENSG00000103363

Encoded Proteins

IDBP-10958

transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)

IDBP-294926

transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)

IDBP-294925

transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)

IDBP-749769

IDBP-754034

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 9918119

TCEB2 is a part of Elongin BC complex, is a component of a multiprotein SOCS1 complex that attenuates JAK/STAT signaling by binding to JAK2 and inhibiting JAK2 kinase and by interacting with SOCS box, the Elongin BC complex can increase expression of the SOCS1 protein by inhibiting its degradation.

PMID 10051596

TCEB2, as a part of the Elongin B and C complex, is bound by SOCS protein for proteasomal degradation.

Entrez Gene

Summary

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:2771414-2777297

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000262306	ENSP00000262306
ENST00000409906	ENSP00000386652
ENST00000409477	ENSP00000387189
ENST00000494946	ENSP00000458213
ENST00000572954	ENSP00000458443

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 158 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	158 [view]
Protein-Protein	158 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006414	translational elongation
GO:0006461	protein complex assembly
GO:0010467	gene expression
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0045087	innate immune response (InnateDB)
GO:0050434	positive regulation of viral transcription
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0031462	Cul2-RING ubiquitin ligase complex
GO:0031466	Cul5-RING ubiquitin ligase complex
GO:0070062	extracellular vesicular exosome
GO:0070449	elongin complex