Homo sapiens Gene: KREMEN2
Summary
InnateDB Gene IDBG-11178.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KREMEN2
Gene Name kringle containing transmembrane protein 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131650
Encoded Proteins
kringle containing transmembrane protein 2
kringle containing transmembrane protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:2963944-2968383
Strand Forward strand
Band p13.3
Transcripts
ENST00000303746 ENSP00000304422
ENST00000319500 ENSP00000322079
ENST00000572045 ENSP00000460578
ENST00000571007 ENSP00000461860
ENST00000575885 ENSP00000459878
ENST00000575769 ENSP00000460917
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signal Transduction pathway
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
INOH
Wnt signaling pathway pathway
PID BIOCARTA
Segmentation clock [Biocarta view]
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Wnt lrp6 signalling [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
Wnt signaling pathway [Biocarta view]
PID NCI
Presenilin action in Notch and Wnt signaling
Cross-References
SwissProt Q8NCW0
TrEMBL
UniProt Splice Variant
Entrez Gene 79412
UniGene Hs.661128
RefSeq NM_172229 NM_001253725 NM_001253726 NM_024507
HUGO HGNC:18797
OMIM 609899
CCDS CCDS10483 CCDS58413 CCDS58412 CCDS10484
HPRD 13933
IMGT
EMBL AB086355 AB086356 AB086357 AB086405 AC004235 AK027669 AK075033 AK301953 BC003533 BC009383 CH471112
GenPept AAH03533 AAH09383 BAB55281 BAC00823 BAC00824 BAC00825 BAC00872 BAC11365 BAG63368 EAW85449
RNA Seq Atlas 79412