Homo sapiens Gene: EGR3
Summary
InnateDB Gene IDBG-11219.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EGR3
Gene Name early growth response 3
Synonyms EGR-3; PILOT;
Species Homo sapiens
Ensembl Gene ENSG00000179388
Encoded Proteins
early growth response 3
early growth response 3
early growth response 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:22687659-22693302
Strand Reverse strand
Band p21.3
Transcripts
ENST00000317216 ENSP00000318057
ENST00000522910 ENSP00000430310
ENST00000519492 ENSP00000429370
ENST00000524088
ENST00000518773
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 0
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007274 neuromuscular synaptic transmission
GO:0007422 peripheral nervous system development
GO:0007517 muscle organ development
GO:0007623 circadian rhythm
GO:0033089 positive regulation of T cell differentiation in thymus
GO:0035767 endothelial cell chemotaxis
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0043066 negative regulation of apoptotic process
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045586 regulation of gamma-delta T cell differentiation
GO:0071320 cellular response to cAMP
GO:0071371 cellular response to gonadotropin stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Cross-References
SwissProt Q06889
TrEMBL B4DH80
UniProt Splice Variant
Entrez Gene 1960
UniGene Hs.534313 Hs.624304
RefSeq NM_001199880 XM_005273426 NM_001199881 NM_004430
HUGO HGNC:3240
OMIM 602419
CCDS CCDS56528 CCDS6033
HPRD 03881
IMGT
EMBL AC105046 AK292464 AK294968 AK295134 AK313604 BC104765 BC112279 S40832 X63741
GenPept AAB19317 AAI04766 AAI12280 BAF85153 BAG36369 BAG58041 BAG58157 CAA45275
RNA Seq Atlas 1960