InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EGR3

Summary

InnateDB Gene

IDBG-11219.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EGR3

Gene Name

early growth response 3

Synonyms

EGR-3; PILOT

Species

Homo sapiens

Ensembl Gene

ENSG00000179388

Encoded Proteins

IDBP-11223

early growth response 3

IDBP-476970

early growth response 3

IDBP-481611

early growth response 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:22687659-22693302

Strand

Reverse strand

Band

p21.3

Transcripts

ENST00000317216	ENSP00000318057
ENST00000522910	ENSP00000430310
ENST00000519492	ENSP00000429370
ENST00000524088
ENST00000518773

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	0
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007274	neuromuscular synaptic transmission
GO:0007422	peripheral nervous system development
GO:0007517	muscle organ development
GO:0007623	circadian rhythm
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0035767	endothelial cell chemotaxis
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0043066	negative regulation of apoptotic process
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045586	regulation of gamma-delta T cell differentiation
GO:0071320	cellular response to cAMP
GO:0071371	cellular response to gonadotropin stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000033730

View Gene Order

ENSBTAG00000019293

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

nfat_tfpathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Cross-References

SwissProt

Q06889

TrEMBL

B4DH80 E5RIM5

UniProt Splice Variant

Entrez Gene

1960

UniGene

Hs.534313 Hs.624304

RefSeq

NM_001199880 NM_001199881 NM_004430 XM_005273426

HUGO

HGNC:3240

OMIM

602419

CCDS

CCDS56528 CCDS6033

HPRD

IMGT

EMBL

AC105046 AK292464 AK294968 AK295134 AK313604 BC104765 BC112279 S40832 X63741

GenPept

AAB19317 AAI04766 AAI12280 BAF85153 BAG36369 BAG58041 BAG58157 CAA45275

RNA Seq Atlas

1960